CDC PROTOCOL OUTCOMES IN TYPE 2 DIABETES AT NAVI MUMBAI-AIROLI: HBA1C RESPONSE AND ANTHROPOMETRIC CHANGES IN 17 DM PACKAGE PATIENTS — A RETROSPECTIVE ANALYSIS

Background: Navi Mumbai-Airoli's DM Package cohort is predominantly female (52.9%) with moderate baseline glycaemic control (HbA1c 8.85%). As a smaller satellite clinic, it provides focused evidence for CDC protocol efficacy in the Airoli residential community. Objective: To evaluate the effect of the Madhavbaug CDC Panchakarma-based multimodal protocol on glycaemic, anthropometric, cardiometabolic, and medication parameters exclusively in DM Package patients (n=17) at the Navi Mumbai (Airoli) Central RIC clinic. Methods: Retrospective observational study. 17 T2DM patients enrolled in the DM Package at Navi Mumbai (Airoli) Central RIC. Only DM Package care plans (CDC-SP Base/1/2/3, CDC-KP Base/1/2/3, DM-HTN 1/2/3) included. Paired Student's t-test (two-tailed) for within-group pre–post comparisons (p<0.05 significant). Descriptive statistics as mean ± SD. Results: HbA1c declined significantly from 8.79±2.13% to 7.36±0.94% (Δ −1.43%, −16.3%, p=0.032, n=12). Weight reduced from 68.49±9.50 to 66.54±9.98 kg (Δ −1.96 kg, −2.9%, p=0.009, n=16). RBS showed minimal change (−2.79 mg/dL, p=0.893), likely due to heterogeneous follow-up timing. BMI trend: −1.00 kg/m² (−3.7%, p=0.086, n=7). Conclusion: Navi Mumbai-Airoli's DM Package demonstrates significant HbA1c reduction of 16.3% (8.79% → 7.36%, p=0.032) and weight reduction of 2.9% (p=0.009), confirming the CDC protocol's glycaemic and anthropometric efficacy in this smaller clinic cohort. The non-significant RBS change likely reflects limited paired data and variable follow-up rather than absent effect.

• International Diabetes Federation (IDF). Diabetes Atlas, 10th Edition. Brussels: IDF, 2021.
• Mohan V, et al. Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res., 2007; 125(3): 217–230.
• Charaka Samhita, Chikitsa Sthana, Prameha Chikitsa, Chapter 6. Varanasi: Chaukhamba Sanskrit Pratishthan.
• Sushruta Samhita, Nidana Sthana, Prameha Nidana. Varanasi: Krishnadas Academy.
• Shanmugasundaram ER, et al. Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts. J Ethnopharmacol, 1990; 30(3): 265–279.
• Singh J, et al. Berberis aristata: A review. Phytother Res., 2003; 17(5): 439–444.
• Lean ME, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 2018; 391(10120): 541–551.
• American Diabetes Association. Standards of Medical Care in Diabetes – 2024. Diabetes Care, 2024; 47(Suppl 1).
• Whelton PK, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. Hypertension, 2018; 71(6): e13–e115.
• Patwardhan B, et al. Ayurveda and natural products drug discovery. Curr Sci., 2004; 86(6): 789–799.