Persistent sorrow and disinterest are hallmarks of depression, a severe mood disorder that affects a person's feelings, thoughts, and day-to-day functioning. A number of biochemical, genetic, environmental, and psychological factors—including brain chemistry, family history, stressful life experiences, and specific medical conditions—combine to cause it. Because of social pressure and embarrassment, most people do not want to admit it. However, individuals are gradually coming to terms with the difficulties associated with mental health and learning to accept them. Vishada and Avasada are two illnesses listed in Ayurvedic literature that closely resemble depression. According to Vishado Rogavardhanam, which Acharaya Charak quotes, it is the primary cause that exacerbates any illness. Depression's psychopathology may even reach the somatic level. Given the numerous connections, it is crucial to comprehend the pathology of depression using fundamental Ayurvedic concepts like Sharirika Dosha (bodily humour), Manasika Dosha (psychological attributes), Satwa Bala (strength of mind), Agni (biological fire), Dhathu (tissues supporting the body), Srotas (channels or pathways of the body), and Ojas (vital essence of life). Psychotherapy, medicine, and lifestyle modifications including exercise are frequently used in combination as treatments. A greater knowledge of depression can aid in its effective prevention and treatment, lessen the stigma attached to the illness, and encourage more people to get treatment.